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Emissive base analogs are powerful tools for probing nucleic acids at the molecular level.
Herein we describe the development and thorough characterization of Exceptionally bright adenine pAa versatile base analog with exceptional fluorescence properties.
When Exceptionally bright into DNA, pA pairs selectively with thymine without perturbing the B-form structure and is among the brightest nucleobase analogs reported so far.
The high brightness at emission wavelengths above nm also makes it suitable for fluorescence microscopy, as demonstrated by imaging of single liposomal constructs coated with cholesterol-anchored pA—dsDNA, using total internal reflection fluorescence microscopy. Exceptionally bright, pA is Exceptionally bright highly promising for two-photon excitation at nm, with a brightness 5.
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